| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220122 | Tetrahedron | 2011 | 6 Pages |
Abstract
A new strategy has been designed for the preparation of gem-difluoro-bisarylic derivatives. It starts from easily accessible and reactive gem-difluoro-propargylic intermediates and elaborates the aromatic rings by a Diels-Alder-aromatization sequence. Heterocyclic systems can be also obtained by 1,3 dipolar cycloadditions, affording mixed aromatic/heteroaromatic derivatives with CF2 as a linker. Since this motif is a bioisostere of O and CO, corresponding bisarylic scaffolds could be of use to prepare chemical libraries of fluorinated analogues of bioactive natural products and/or drugs.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ali Khalaf, Danielle Grée, Hassan Abdallah, Nada Jaber, Ali Hachem, René Grée,