| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220143 | Tetrahedron | 2012 | 6 Pages |
Abstract
A new, concise, and efficient route for the synthesis of 1-aminoisoquinolines in good to excellent yields is described; this involves the reaction of 2-alkynylbenzaldoximes and isothiocyanates, which is catalyzed by silver triflate in dichloromethane, at room temperature. This transformation involves tandem 6-endo cyclization, [3+2] cycloaddition, and subsequent rearrangement. The simple operational protocol provides a cost-effective, diversity-oriented route to 1-aminoisoquinolines under neutral, mild conditions.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
