| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220158 | Tetrahedron | 2012 | 7 Pages |
Abstract
A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Karel Piron, Sara Kenis, Guido Verniest, Riccardo Surmont, Jan Willem Thuring, Peter ten Holte, Frederik Deroose, Norbert De Kimpe,