Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220175 | Tetrahedron | 2011 | 7 Pages |
Abstract
A mild, efficient, and regioselective carbanion-yne intramolecular cyclization mediated by t-BuOK for the synthesis of 2-substituted 3-benzylbenzofurans is developed. It was started from o-iodophenol (1), based on O-alkylation, and the Sonogashira reaction in sequence to produce 2-(2-phenylethynylphenoxy)-1-arylalkanones (5). An intramolecular carbanion-yne 5-exo-dig cyclization reaction of 5, which was mediated by t-BuOK, yielded title benzofurans in good yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Po-Yuan Chen, Tzu-Pin Wang, Keng-Shiang Huang, Chai-Lin Kao, Jui-Chi Tsai, Eng-Chi Wang,