Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220221 | Tetrahedron | 2012 | 9 Pages |
Abstract
A target-oriented highly enantioselective multifunctional organocatalytic approach has been developed to construct the bicycle-[3.3.1]nona-2,6-dien-9-one core of (â)-huperzine A for the first time, with up to 95% ee in the gram-scale procedure. The newly established methodology is also eligible to synthesize a variety of bicyclo[3.3.1]nona-2,6-dien-9-ones in high enantiopurities, and thus is useful for the future development of novel huperzine A analogs with medicinal interests.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiao-Hua Ding, Xiang Li, Dan Liu, Wei-Chen Cui, Xuan Ju, Shaozhong Wang, Zhu-Jun Yao,