Article ID Journal Published Year Pages File Type
5220262 Tetrahedron 2011 6 Pages PDF
Abstract

Synthesis of a potential Src family SH2 domain inhibitor incorporating a 1,4-cis-enediol scaffold is reported. The synthetic route offers straightforward and highly selective access to the enediol and its associated chiral centers. Key steps include stereocontrolled syn-aldol coupling, amide alkynylation, and asymmetric ketone reduction.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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