Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220262 | Tetrahedron | 2011 | 6 Pages |
Abstract
Synthesis of a potential Src family SH2 domain inhibitor incorporating a 1,4-cis-enediol scaffold is reported. The synthetic route offers straightforward and highly selective access to the enediol and its associated chiral centers. Key steps include stereocontrolled syn-aldol coupling, amide alkynylation, and asymmetric ketone reduction.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christine Marian, Rong Huang, Richard F. Borch,