Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220263 | Tetrahedron | 2011 | 7 Pages |
Abstract
A short and facile synthesis of (S)-felodipine was developed starting from (R)-glycidol as the source of the chiral auxiliary. 2-Hydroxyethyl esters were found to undergo selective transesterification reactions in the presence of other esters. This selective transesterification reaction was applied to the synthesis of (S)-felodipine through selective substitution of the 2-hydroxyethyl group possessing chiral ester with sodium methoxide.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kuktae Kwon, Jung A. Shin, Hee-Yoon Lee,