Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220266 | Tetrahedron | 2011 | 12 Pages |
Abstract
We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6Ï-electrocyclization, an alkylative dearomatization, and the stereoselective functionalization of the cortistatin A-ring. While the total synthesis we sought was not accomplished, the work sets the stage for several approaches to the preparation of novel analogs via diverted total synthesis.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhang Wang, Mingji Dai, Peter K. Park, Samuel J. Danishefsky,