| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220267 | Tetrahedron | 2011 | 6 Pages |
Abstract
The design, synthesis, and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a hedgehog signaling inhibitor, are described. Structure-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.
Graphical abstractThe design synthesis, and biological evaluation of 6, 7, 8, and 16, which serve as mimics of the potent hedgehog inhibiting substance cyclopamine 1, are described.Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffrey D. Winkler, André K. Isaacs, Chaomei Xiang, Valérie Baubet, Nadia Dahmane,