Article ID Journal Published Year Pages File Type
5220292 Tetrahedron 2011 10 Pages PDF
Abstract

Two different strategies for the synthesis of spongidines A and D are presented. Herein we describe a route based in an amino acid insertion followed by aromatization. Another alternative is the construction of a pyridine derivative followed by N-alkylation. Both methodologies have intermediate 5 as a key compound, which is eventually accessible from methyl isoanticopalate.

Graphical abstractSpongidines A and D have been synthesized. Two routes have been optimized and the key compound is chloroderivative 13.Download full-size image

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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