Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220292 | Tetrahedron | 2011 | 10 Pages |
Abstract
Two different strategies for the synthesis of spongidines A and D are presented. Herein we describe a route based in an amino acid insertion followed by aromatization. Another alternative is the construction of a pyridine derivative followed by N-alkylation. Both methodologies have intermediate 5 as a key compound, which is eventually accessible from methyl isoanticopalate.
Graphical abstractSpongidines A and D have been synthesized. Two routes have been optimized and the key compound is chloroderivative 13.Download full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
P. Basabe, A. Blanco, I.S. Marcos, D. DÃez, O. Bodero, M. MartÃn, J.G. Urones,