Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220388 | Tetrahedron | 2012 | 4 Pages |
Abstract
Strategically placed covalent linkages have been shown to stabilize helical conformations in short peptide sequences. Here we report the synthesis of a stabilized α-helix that utilizes an internal disulfide linkage. Structural analysis indicates that the dynamic nature of the disulfide bridge allows for the reversible formation of an α-helix through oxidation and reduction reactions.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stephen E. Miller, Neville R. Kallenbach, Paramjit S. Arora,