| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220397 | Tetrahedron | 2012 | 5 Pages |
Abstract
The design and synthesis of substituted bis- and tris-benzamides is reported in which the projection of side-chain residues on both sides of an α-helix is reproduced. The scaffold is conformationally constrained by a series of intramolecular hydrogen bonds, allowing for spatial and angular mimicry of the i, i+2, i+4 and i+6 side-chains in the case of the bis-benzamide, and may be extended to higher-order oligomers.
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Physical Sciences and Engineering
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