| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220410 | Tetrahedron | 2011 | 8 Pages |
Abstract
A new method for synthesis of rodocaine (1) is presented. Two key steps were carried out by the N-bromosuccinimide (NBS)-mediated intermolecular addition of known enamine 5 with allyltrimethyl silane in presence of boron trifluoride etherate (BF3/OEt2) and the intramolecular ring-closing metathesis of triene 3. The Diels–Alder cycloaddition of triene 3 with different ethyl propiolates was also studied.
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