Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220411 | Tetrahedron | 2011 | 5 Pages |
Abstract
Syntheses of 16-membered macrolactams, which were aza-analogues of macrosphelides, could be established effectively by a ring-closing metathesis (RCM) strategy. Novel 19 analogues and six aza-macrosphelide-epothilone hybrids were furnished according to simple operations. Biological assay of these artificial aza-macrosphelides revealed that some of them showed stronger apoptosis-inducing activity against human lymphoma cells than the parent compound.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kenji Sugimoto, Yuta Kobayashi, Ayana Hori, Takashi Kondo, Naoki Toyooka, Hideo Nemoto, Yuji Matsuya,