| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220418 | Tetrahedron | 2011 | 5 Pages |
Abstract
Several estrogens were mono-formylated using a mixture of paraformaldehyde, MgCl2, and Et3N in refluxing THF. In all cases, the 2-isomer was formed as the major product with high regioselectivity compared to the 4-isomer. Excellent to high yields were obtained in all examples except one. The method was applied for an efficient synthesis of the anti-cancer agent 2-methoxyestradiol.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ãyvind W. Akselsen, Trond Vidar Hansen,