| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220430 | Tetrahedron | 2011 | 9 Pages |
Abstract
An efficient approach to trans-4-hydroxylpyrrolidine lactams 1 starting from amino acid is described. The utility of this method has been demonstrated in the synthesis of antipsychotic nemonapride 3 and antiangiogenic streptopyrrolidine 4. Compared four synthetic stereoisomers of natural streptopyrrolidine 4 in term of spectroscopic and physical data, the absolute structure of the natural product was proposed as (4S,5S)-configuration.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wei Huang, Jing-Yi Ma, Mu Yuan, Long-Fei Xu, Bang-Guo Wei,