Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220497 | Tetrahedron | 2011 | 10 Pages |
Abstract
The base-induced cyclization of (E)-2-aryl-1-[2-(benzylsulfonyl)phenyl]-1-nitroethenes to polysubstituted thiochroman S,S-dioxides exhibits a diastereoselectivity that can be oriented towards a selected isomer by means of appropriate adjustments of the experimental conditions. The interest of such a result also rests on the promising pharmacological activity of the products, whose structure encompasses different well-acknowledged pharmacophores. A conformational 1H NMR investigation, backed by molecular-mechanics calculations, has also been accomplished.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lara Bianchi, Massimo Maccagno, Giovanni Petrillo, Egon Rizzato, Fernando Sancassan, Domenico Spinelli, Cinzia Tavani,