| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220532 | Tetrahedron | 2011 | 7 Pages |
Abstract
A small library of 1-(isoquinolin-1-yl)guanidine is constructed efficiently via a silver triflate-catalyzed three-component reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, with carbodiimide. The preliminary biological screens of these isoquinoline library members have been evaluated, which show promising results as PTP1B inhibitor and HCT-116 inhibitor.
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