| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220626 | Tetrahedron | 2011 | 4 Pages |
Abstract
The use of tubulin as a target to influence the composition of the mixture from a dynamic combinatorial library, based on the disulfide bond exchange reaction, is described. ESI-FT-ICR-MS was used to determine the composition of the library. The heterodimeric compound amplified by this approach was used to design the homologous derivative with a two-carbon spacer in place of the disulfide function. The ability of the compounds to inhibit tubulin polymerization is reported and compared to thiocolchicine.
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Chemistry
Organic Chemistry
Authors
Graziella Cappelletti, Daniele Cartelli, Bruno Peretto, Micol Ventura, Marco Riccioli, Francesco Colombo, John S. Snaith, Stella Borrelli, Daniele Passarella,