Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220628 | Tetrahedron | 2011 | 9 Pages |
Abstract
Replacement of terminal atoms of Br in 1,3-bis(bromopentyl)-5(6)-substituted uracils with 2-mercapto-5-methyl-1,3,4-thiadiazole, 2,5-dimercapto-1,3,4-thiadiazole, 2-mercaptoimidazole, and 2-mercaptobenzimidazoles resulted in a series of acyclic compounds and isomeric heterocyclophanes. Structures of macrocyclic regioisomers were unambiguously determined by NMR data. One of the regioisomers exhibits a hypochromic effect with respect to model compounds. The acyclic uracils obtained bridged with five-membered heterocycles are alkylated with methyliodide and methyl tosylate, and oxidated with m-CPBA, H2O2, and I2.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vyacheslav E. Semenov, Evgeniya S. Krylova, Irina V. Galyametdinova, Alla V. Chernova, Sergey V. Kharlamov, Shamil K. Latypov, Vladimir S. Reznik,