Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220647 | Tetrahedron | 2012 | 8 Pages |
Abstract
An efficient and straightforward nucleophilic difluoromethylation of CN bonds in heterocycles under the activation of alkylating agents has been developed. Cyclic iminium salts derived from dihydroisoquinolines, quinolines, and pyridines were successfully difluoromethylated with sulfur-based fluoroalkyl silanes affording a series of new difluoromethylated nitrogen-containing heterocyclic compounds.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Weizhou Huang, Chuanfa Ni, Yanchuan Zhao, Wei Zhang, Alexander D. Dilman, Jinbo Hu,