Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220653 | Tetrahedron | 2012 | 7 Pages |
Abstract
By using iridium catalyst based on chiral spiro phosphine-oxazoline ligands, the hydrogenation of α-arylcinnamic acids was accomplished under ambient pressure and low catalyst loading (as low as 0.01 mol %), providing useful 2,3-diarylpropionic acids in high yields with excellent enantioselectivities (up to 99% ee). A catalytic enantioselective synthesis of (S)-equol with the present hydrogenation reaction as a key step was accomplished starting from commercially available starting materials in six steps with 48.4% overall yield.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shuang Yang, Shou-Fei Zhu, Can-Ming Zhang, Song Song, Yan-Bo Yu, Shen Li, Qi-Lin Zhou,