| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220657 | Tetrahedron | 2012 | 6 Pages |
Abstract
A multi-component reaction of 2-alkynylbenzaldehyde, 4-methylbenzenesulfonohydrazide, carbodiimide, and bromine is reported, which generates 1-(4-bromoisoquinolin-1-yl)guanidines in good yields under mild conditions. The products could be further elaborated via a palladium-catalyzed Suzuki–Miyaura coupling reaction, leading to the diverse 1-(isoquinolin-1-yl)guanidines.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
