Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220659 | Tetrahedron | 2012 | 7 Pages |
Abstract
This article describes an efficient method for the preparation of chiral chroman derivatives by the Pd(II)-catalyzed asymmetric Wacker-type cyclization using a chelation-induced axially chiral tetraoxazoline ligand. Under the optimized conditions, up to 80% yield and up to 92% ee were obtained. This is the first example to utilize o-trisubstituted 3-butenylphenols as substrates in such transformation.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qingchuan Liu, Ke Wen, Zhenfeng Zhang, Zhengxing Wu, Yong Jian Zhang, Wanbin Zhang,