Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220680 | Tetrahedron | 2011 | 6 Pages |
Abstract
An efficient one-pot method to access 2-amino-1,3,4-oxadiazoles from isoselenocyanates and hydrazides or dihydrazides was developed via cyclodeselenization. Without any harsh reagents, various 2-amino-1,3,4-oxadiazoles were obtained in considerably high yields (82%-97%) and purities (>99%) directly with simple crystallization in ethanol. And the formed precipitated Se powder during the reaction could be recycled for preparation of isoselenocyanates efficiently. A plausible mechanism is proposed for the formation of the target products.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuanyuan Xie, Junli Liu, Ping Yang, Xiangjun Shi, Jianjun Li,