| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220697 | Tetrahedron | 2011 | 7 Pages |
Abstract
An efficient method for the synthesis of nucleoside phosphoramidates prodrugs (6a-f) has been developed that employs a simple protection/deprotection sequence of the nucleoside with benzyloxycarbonyl (Cbz). The coupling reaction of Cbz-protected derivatives (5a-f) with phenyl-(ethoxy-l-alaninyl)-phosphorochloridate (7), followed by Cbz group removal by hydrogenolysis provided the phenyl phosphoramidate ProTides (6a-f) in excellent overall yields.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jong Hyun Cho, Franck Amblard, Steven J. Coats, Raymond F. Schinazi,