| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220700 | Tetrahedron | 2011 | 9 Pages |
Abstract
A practical system for synthesizing the multiple-substituted 2,5-dihydrofuran through intermolecular dipolar cycloaddition reactions of acceptor/acceptor diazo reagents, aldehydes, and acetylenedicarboxylate was developed. The reactions proceeded effectively under ambient temperature with low reactant ratios. The control reactions revealed that there are two competitive paths: one forms 1,3-dioxolane and the other forms 2,5-dihydrofuran. These two paths could be controlled by modifying the steric hindrance of the diazo reagents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shifa Zhu, Lijuan Chen, Chao Wang, Renxiao Liang, Xiujun Wang, Yanwei Ren, Huanfeng Jiang,