Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220713 | Tetrahedron | 2012 | 6 Pages |
Abstract
Synthesis of new 2,3-diaryl-3H-pyrrolo[2,3-c]isoquinoline derivatives has been elaborated starting from isoquinoline-3-amine. Buchwald-Hartwig arylation and subsequent iodination in position 4 afforded 3-arylamino-4-iodoisoquinolines. These compounds were subjected to Sonogashira cross-coupling reactions with some selected acetylenes, and the resulting coupled products underwent cyclization in the presence of tetrabutylammonium fluoride to give title derivatives.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bharat Dixit, József Balog, Zsuzsanna Riedl, László Drahos, György Hajós,