| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220765 | Tetrahedron | 2011 | 10 Pages |
Abstract
Studies directed toward the synthesis of the architecturally complex marine natural product sporolide BÂ are described. Synthetic analysis suggested advanced hydroquinone and benzodiquinane fragments, which upon elaboration were successfully united via an ester linkage. Macrocyclization studies were then carried out, and although a novel macrocyclization product was obtained, subsequent studies revealed that the tertiary hydroxyls at C(6) and C(10) were too sterically encumbered to participate in a successful macrocyclization to furnish sporolide B.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jeffery A. Gladding, James P. Bacci, Scott A. Shaw, Amos B. III,