| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220843 | Tetrahedron | 2011 | 5 Pages |
Abstract
An 18F-labelled 2,5-diaryl tetrazole reagent has been prepared and reacted with substituted alkene dipolarophiles through a photoactivated 1,3-dipolar cycloaddition reaction. The radiobioconjugation reaction furnished the desired product in 5 min with radiochemical conversions of 85-95% at room temperature. Remarkably, for the activated dipolarophiles, these results were obtained in highly dilute solutions (10-100 μM).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
David Thonon, Eve Goukens, Geoffroy Kaisin, Jérôme Paris, Jessica Flagothier, André Luxen,