| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220875 | Tetrahedron | 2012 | 7 Pages |
Abstract
Chiral nonracemic N-(diphenylphosphinoyl)-protected propargylic amines have been prepared by addition of terminal alkynes to N-(diphenylphosphinoyl)aldimines in the presence of dimethylzinc and 3,3′-dibromo-BINOL as catalyst. The reaction works with a variety of aromatic and heteroaromatic aldimines and with different alkynes, providing the expected products in generally good yields and enantiomeric excesses (up to 96%).
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