| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220893 | Tetrahedron | 2010 | 5 Pages |
Abstract
The enantioselective synthesis of 3(S)-hydroxy polygodial and its acetyl derivative is described. The construction of the 3-hydroxy drimane skeleton was based on the titanium-catalyzed radical cyclization of (10S)-10, 11-epoxy-farnesyl acetate. Only underivatized 3(S)-hydroxy polygodial showed activity in assays on VR1 vanilloid receptor in HEK cells transfected with the human VR1.
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Chemistry
Organic Chemistry
Authors
Mariantonietta D'Acunto, Carmela Della Monica, Irene Izzo, Luciano De Petrocellis, Vincenzo di Marzo, Aldo Spinella,