Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5220953 | Tetrahedron | 2012 | 6 Pages |
Abstract
(â)-Jorumycin and its 15 C-22 analogues were prepared employing l-tyrosine as the chiral starting material via 21 steps. These analogues, along with (â)-jorumycin itself, were evaluated in vitro for cytotoxicity against HCT-8, BEL-7402, Ketr3, A2780, MCF-7, A549, BGC-823, Hela, HELF, and KB cells. The IC50 values of the cytotoxicity of most of these analogs were at the level of nM, which was similar to that of (â)-jorumycin. Among these analogs including (â)-jorumycin, hippuric acid ester derivative 23 exhibited the most potent and broad-spectrum cytotoxic activity against the ten cell lines with an average IC50 of 2.12 nM.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Wei Liu, Xiangwei Liao, Wenfang Dong, Zheng Yan, Nan Wang, Zhanzhu Liu,