| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5220970 | Tetrahedron | 2012 | 7 Pages |
Abstract
A metal-free catalytic method for the conversion of aromatic and aliphatic aldoximes to nitriles at room temperature using oxalyl chloride (1.2 equiv) in combination with 5 mol % of triphenylphosphine oxide is reported. Of the many potential pathways leading from oxime to nitrile a manifold involving chlorophosphonium salt-catalysed decomposition of oxime chlorooxalates formed in situ is shown to be operative.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
