Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221002 | Tetrahedron | 2011 | 10 Pages |
Abstract
A series of unsaturated acyclonucleoside bis(POC) prodrugs of E configuration were synthesized through an expeditious, highly efficient and stereoselective one-step procedure from corresponding bis(POC)allylphosphonate through Ru catalyzed cross-coupling metathesis reaction. The [RuCl2(PCy3)(SIPr)(Indenylidene)] and [RuCl2(PCy3)(IMes)(benzylidene)] catalysts were employed; the unsaturated ANP were used bore C5-halovinyl uracil, C5-dihalovinyluracil or furanopyrimidine motifs. The chemical cleavage of biolabile (POC) group is a useful pathway to acid phosphonate derivatives.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aurélien Montagu, Ugo Pradére, Vincent Roy, Steven P. Nolan, Luigi A. Agrofoglio,