Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221004 | Tetrahedron | 2011 | 7 Pages |
Abstract
A new 'one-flask' synthesis of 3,5-disubstituted 1,2,4-triazoles has successfully been developed to synthesize a series of 3,5-disubstituted 1,2,4-triazoles. The transformation involves the 1,3-dipolar cycloaddition reaction of hydrazonoyl hydrochlorides with oxime intermediates prepared from aldehydes with hydroxylamine hydrochloride in the presence of excess amount of triethylamine. In this 'one-flask' 1,3-dipolar reaction, hydrazonoyl hydrochlorides was concerned as the masked 1,3-dipole nitrilimine under basic condition. Furthermore, this newly developed methodology can be applied to various aldehyde substrates including aliphatic, cyclic aliphatic, aromatic, and heterocyclic aldehydes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wen-Che Tseng, Li-Ya Wang, Tian-Shung Wu, Fung Fuh Wong,