Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221025 | Tetrahedron | 2012 | 12 Pages |
Abstract
An efficient synthesis of 3-alkyl 1,5,3-dioxazepanes was developed for subsequent use in double-Mannich reactions with a variety of carbon-based nucleophiles. It was found that addition of methyltrichlorosilane to the dioxazepane led to a long-lasting reactive species that reacted rapidly with acid-sensitive ketones and β-ketoesters to afford azabicyclo[3.3.1]nonanes in good yield.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kevin Sparrow, David Barker, Margaret A. Brimble,