| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5221037 | Tetrahedron | 2012 | 8 Pages |
Abstract
A novel asymmetric aldol-reduction-etherification process of aliphatic enolizable aldehydes is described. The intermediately formed aldol adducts-β-hydroxyaldehydes-were reduced and transformed into the corresponding 1,3-diol ethers by external secondary alcohols at the same time. Thus, with the help of chiral secondary alcohols an access to optically active 1,3-diol ether is given. Furthermore, asymmetric cross-aldol-Meerwein-Ponndorf reactions of enolizable aldehydes can also be realized under these reaction conditions.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrea Seifert, Kerstin Rohr, Rainer Mahrwald,