Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221052 | Tetrahedron | 2012 | 9 Pages |
Abstract
Conformationally restricted 2â²-C-azido-, hydroxy- and fluoromethyl-carbanucleosides 4b-f were efficiently synthesized via the stereoselective conversion of ketone 7 to epoxide 14, followed by the stereoselective opening of the epoxide with nucleophiles (OAc, N3, and F), while the corresponding 2â²-C-methyl-carbanucleoside 4a was synthesized via the stereoselective Grignard reaction of ketone 7 with methylmagnesium iodide as a key step. All the final nucleosides 4a-f were assayed for anti-HCV activity, but showed neither significant anti-HCV activity nor cytotoxicity in a cell-based replicon assay.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Won Jun Choi, Yun Jung Ko, Girish Chandra, Hyuk Woo Lee, Hea Ok Kim, Hyo Jung Koh, Hyung Ryong Moon, Young Hoon Jung, Lak Shin Jeong,