| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5221078 | Tetrahedron | 2010 | 5 Pages |
Abstract
A series of pyrrolidine-urea bifunctional organocatalysts was efficiently synthesized and applied to the asymmetric Michael addition of ketone to nitroolefin. Theoretical study was performed to shed light on the origin of their different activities and revealed that the rigid structure formed between catalyst 1b with nitroolefin via double hydrogen bonding retarded the approach of nucleophilic enamine intermediate.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiao-Yu Cao, Jun-Cheng Zheng, Yu-Xue Li, Zhen-Cao Shu, Xiu-Li Sun, Bi-Qin Wang, Yong Tang,