Metal-organic framework Cu3 (BTC)2(H2O)3 catalyzed Aldol synthesis of pyrimidine-chalcone hybrids

A typical metal organic framework, [Cu3 (BTC)2(H2O)3, BTC = 1,3,5-benzene tricarboxylate] has been used for the synthesis of pyrimidine-chalcones. We have explored a green synthesis of pyrimidine chalcones under Cu3(BTC)2 catalysis by Aldol condensation. Easy isolation of product, excellent yield, and recyclable catalyst makes this reaction eco-friendly. The technology was demonstrated to be applicable to the synthesis of a host of chemical hybrids.

Graphical abstractCu3 (BTC)2(H2O)3, a metal organic framework exhibiting a hard Lewis acid character, gives an excellent yield and easily recyclable catalyst for the synthesis of pyrimidine-chalcone hybrids by Aldol condensation reaction at 40 °C.Figure optionsDownload full-size imageDownload as PowerPoint slideResearch Highlights► Cu3(BTC)2(H2O)3, a metal organic framework exhibits Lewis acid character, gives excellent yields for synthesis of pyrimidine-chalcone-hybrids via Aldol condensation. ► Highlight of the reaction: 0.075 g of Cu-BTC reused in all reactions up to 11th cycle. ► Remarkable features exhibited:mild reaction conditions, enhanced rates,improved efficiency, maximum atom economy, inexpensive recyclable catalyst, green solvent systems.