| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5221142 | Tetrahedron | 2010 | 6 Pages |
Abstract
Bicyclic nucleoside analogs have shown promise in Antisense and RNA interference strategies. Ribofuranosyl ring conformation is a controlling factor in this regard. We have introduced a spiroisoxazolidine ring at the 2â²-position of the sugar to gauge the effect it has on sugar dynamics. Proton relaxation measurements and coupling constant analysis indicate the sugar is locked in the North conformation with substantial sugar rigidity evident.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Krista Versteeg, Dierdre Zwilling, Hui Wang, Kevin M. Church,