Article ID Journal Published Year Pages File Type
5221161 Tetrahedron 2012 6 Pages PDF
Abstract

Conditions have been developed for the regioselective synthesis of 4-substituted isoxazoles from terminal alkynes and 3,4-disubstituted isoxazoles from internal alkynes. The methodology involves a one-pot titanium-catalyzed multicomponent coupling reaction followed by simple hydroxylamine hydrochloride addition.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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