Article ID Journal Published Year Pages File Type
5221165 Tetrahedron 2012 5 Pages PDF
Abstract

Total synthesis of 2-(2-hydroxyalkyl)-piperidine alkaloids, (−)-halosaline and (−)-8-epi-halosaline is reported from n-butyraldehyde using iterative asymmetric allylation, nucleophilic substitution with an azide and ring-closing metathesis as the key reactions.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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Total synthesis of 2-(2-hydroxyalkyl)-piperidine alkaloids (−)-halosaline and (−)-8-epi-halosaline via iterative asymmetric allylation/RCM strategy
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