| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5221371 | Tetrahedron | 2012 | 6 Pages |
Abstract
In this study, a receptor for phosphorylated peptide was developed. The receptor contains Zn2+-dipicolylamine (Zn-Dpa) moiety at one end and guanidiniocarbonyl pyrrole at the other. The association between the receptor and CTD (carboxy-terminal domain of RNA polymerase II) peptides with different phosphorylated patterns was investigated by isothermal titration calorimetry and molecular docking, and the receptor showed much higher affinity towards bis-phosphorylated CTD peptide with affinity constant K=1.09Ã105.
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Authors
Saihui Zhang, Liang Han, Chuan-guang Li, Jun Wang, Wei Wang, Zhi Yuan, Xueping Gao,