Synthesis of (+)-makassaric acid, a protein kinase MK2 inhibitor

Article ID	Journal	Published Year	Pages	File Type
5221395	Tetrahedron	2010	5 Pages	PDF

Abstract

Description of the first synthesis of (+)-makassaric acid, an important kinase MK2 inhibitor. The key step was a Barton/McCombie radical deoxygenation.

Graphical abstract(+)-Makassaric acid has been synthesized from (â)-sclareol, through a Barton/McCombie reaction.Download full-size image

Keywords

Meroterpenoids Protein kinase inhibitors

Related Topics

Physical Sciences and Engineering Chemistry Organic Chemistry

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Synthesis of (+)-makassaric acid, a protein kinase MK2 inhibitor

Authors

P. Basabe, M. MartÃn, O. Bodero, A. Blanco, I.S. Marcos, D. DÃez, J.G. Urones,