Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221400 | Tetrahedron | 2010 | 7 Pages |
Abstract
Palladium(0)/copper iodide catalyzed Sonogashira cross-coupling of 2-aryl-3-iodo-4-(phenylamino)quinolines with terminal alkynes afforded series of 1,2,4-trisubstituted 1H-pyrrolo[3,2-c]quinolines in a single-step operation. Conversely, the 4-(N,N-allylphenylamino)-2-aryl-3-iodoquinoline derivatives were found to undergo PdCl2(PPh3)2/CuI catalyzed intramolecular Heck reaction to yield the corresponding 1,3,4-trisubstituted 1H-pyrrolo[3,2-c]quinolines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Malose J. Mphahlele, Lehlohonolo G. Lesenyeho, Hlamulo R. Makelane,