| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5221409 | Tetrahedron | 2010 | 8 Pages |
The chemo- and regioselectivity of the reduction, oxidation and Wittig reaction of polyfunctional pyrroles, containing a variety of reactive centres was investigated. The reaction of 3,5-dichloropyrrole-2,4-dicarboxaldehydes with potassium permanganate leads to regioselective oxidation of the 2-formyl group, while the Wittig reaction with 1 equiv of a triphenylphosphorane produced the 2-alkenyl substituted pyrroles.
Graphical abstractThe chemo- and regioselectivity of the reactions of polyfunctional pyrroles, containing a variety of reactive centres is described. Regioselective reduction, oxidation or Wittig reactions give a range of pyrroles suitable for further synthetic transformations.Figure optionsDownload full-size imageDownload as PowerPoint slide
