| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5221414 | Tetrahedron | 2010 | 6 Pages |
Abstract
A convenient, recyclable catalytic synthesis of benzofuran-2-acetic esters 2 by sequential Pd(0)-catalyzed deallylation—Pd(II)-catalyzed carbonylative heterocyclization of 1-(2-allyloxyphenyl)-2-yn-1-ols 1 in ionic liquids is presented. Reactions were typically carried out in BmimBF4 as the solvent at 100 °C and under 30 atm of CO, in the presence of catalytic amounts (1 mol %) of PdI2 in conjunction with KI (1 equiv), PPh3 (4 mol %), MeOH (28 equiv), and H2O (2 equiv). The solvent-catalyst system could be recycled several times without appreciable loss of catalytic activity.
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