Article ID Journal Published Year Pages File Type
5221416 Tetrahedron 2010 7 Pages PDF
Abstract

An extremely short formal synthesis of three epimers of penmacric acid is accomplished starting from pyroglutamate in one or two steps. Stereochemical outcome in the reaction of Li and Ti enolates of pyroglutamate with imines is found to be dependent on both chelation and steric factors.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry