Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5221416 | Tetrahedron | 2010 | 7 Pages |
Abstract
An extremely short formal synthesis of three epimers of penmacric acid is accomplished starting from pyroglutamate in one or two steps. Stereochemical outcome in the reaction of Li and Ti enolates of pyroglutamate with imines is found to be dependent on both chelation and steric factors.
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